Key result
Extended-release paliperidone overdose triggers delayed, sequential dyskinesia, cardiac arrhythmia, and partial seizures.
Why the study?
There are few literature reports describing the clinical features and timing of symptoms following paliperidone overdose.
What are the clinical manifestations and timeline of symptoms following paliperidone overdose?
Case Report (n=1)
No
What are the clinical manifestations and timeline of symptoms following paliperidone overdose?
Paliperidone overdose can cause delayed onset of severe symptoms including dyskinesia, tachycardia, and seizures, warranting prolonged clinical observation.
May warrant prolonged monitoring after paliperidone overdose; leaves open optimal observation protocols.
Paliperidone is a new atypical antipsychotic agent. There are few literature reports of paliperidone overdoses and we report a case of these. A 32-year-old man was admitted to Emergency Department for occurrence of opisthotonus, muscular spasms and rigidity. Twenty hours before, he had an ingestion of 168 mg of paliperidone. He had hypotension and tachycardia. The dystonic reaction completely resolved within a few minutes after diazepam. Nine hours after admission, he sudden showed a right hemisoma partial seizure. The peculiar interest of our case is that three different and rare symptoms occurred in successive times after overdose. Some symptoms occurred after several hours following overdose. Oral paliperidone is available as an osmotic release delivery system that results in a gradual rise in plasma concentrations. According to this limited experience in which delayed onset of toxicity has been observed, it may be prudent to recommend prolonged observation after overdose of paliperidone.
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Villa et al. (2015) conducted a case report in Paliperidone overdose (n=1). Paliperidone overdose was evaluated on Clinical symptoms following overdose. An intentional overdose of 168 mg of extended-release paliperidone in a 32-year-old man resulted in delayed and sequential onset of dyskinesia, cardiac arrhythmia, and a partial seizure.
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