Case report details inadvertent high-dose exposure in a schizophrenia patient, suggesting monitoring for overdose effects.
Paliperidone palmitate is an atypical antipsychotic that can be administered via intramuscular route in one monthly, three monthly and six monthly preparations. Accidental overdose of paliperidone has been reported on several occasions, however the existing published literature only repots on overdoses occurring from cumulative doses over a period of time. We report the case of a 55-year-old male with schizophrenia, admitted with a psychotic relapse and, overdue for his paliperidone three monthly long acting injectable (LAI) 350mg, who inadvertently received 350mg of the 1-monthly preparation in one single administration. Side effects were monitored over a three week period in the inpatient setting during which there were only mild reports of extra-pyramidal side effects. The patient continued to receive follow up through the community mental health team for 6 months with no further adverse effects reported.
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Khalid et al. (2025) studied this question.
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