Key result
Methylphenidate and atomoxetine show no significant effect on intraocular pressure in pediatric ADHD.
Why the study?
The effects of psychopharmacological agents on intraocular pressure in children with ADHD were not well understood.
Does treatment with methylphenidate or atomoxetine affect intraocular pressure in children with ADHD?
Cohort (n=118)
No
Does treatment with methylphenidate or atomoxetine affect intraocular pressure in children with ADHD?
p-value: p=>0.05
Psychopharmacological treatment with methylphenidate or atomoxetine for up to 6 months does not significantly alter intraocular pressure in children with ADHD.
Attention deficit hyperactivity disorder (ADHD) is one of the most common psychiatric conditions in childhood. Psychopharmacological therapy is an effective treatment for ADHD. In this study, we primarily aim to investigate the effects of psychopharmacological agents on intraocular pressure (IOP) in children with ADHD. The sample included 82 children with ADHD and 36 healthy children aged between 8 and 12 years who were referred to the Department of Child and Adolescent Psychiatry in Hatay State Hospital, Hatay, Turkey. Children with ADHD were divided into two groups according to the medication used: methylphenidate (MPH) group and atomoxetine (ATX) group. Before treatment and after 1- and 6-month treatment period, IOP was measured by Goldmann applanation tonometry. There were no statistical differences in terms of age, gender, and IOP between the three groups (P > 0.05). After 1- and 6-month treatment, the IOP did not change significantly between baseline and 1 month or 6 months (P > 0.05). Children with ADHD may have an IOP similar to healthy children. Six-month treatment with MPH or ATX may not cause significant changes in IOP.
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Güvenmez et al. (2020) conducted a cohort in Attention deficit hyperactivity disorder (ADHD) (n=118). Methylphenidate or Atomoxetine vs. Baseline intraocular pressure and healthy controls was evaluated on Change in intraocular pressure from baseline to 1 and 6 months (p=>0.05). Six-month treatment with methylphenidate or atomoxetine did not cause significant changes in intraocular pressure in children with attention deficit hyperactivity disorder.
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