Boron Neutron Capture Therapy for Glioblastoma: Is it Worth Pursuing?

Presently glioblastomas are incurable brain tumors. The prospect of treating this deadly disease has been the major justification for the current programs of boron neutron capture therapy (BNCT) throughout the world. However, based on pharmacological and cell biological considerations, it is improbable that BNCT will ever be an effective therapy for this tumor. Indeed, a review of the published literature over the last 50 years fails to provide justification for developing BNCT past its present experimental stage.