Key result
DDX3 promotes HIV and HCV replication while driving innate antiviral signaling targeted by other viruses.
Why the study?
Human DDX3 is a key RNA helicase targeted by viruses, but its dual role in viral replication and innate antiviral signalling is not fully understood.
This review highlights the dual role of human DDX3 in viral infections, where it is exploited by HIV and HCV for replication but inhibited by other viruses to evade innate antiviral signaling.
DDX3 modulation should not yet guide antiviral strategies; leaves open its selective therapeutic potential pending dedicated studies.
Human DDX3 is a DEAD (Asp-Glu-Ala-Asp)-box RNA helicase that appears to be a prime target for viral manipulation. While two viruses that manifest major global health threats, HIV and HCV (hepatitis C virus), utilize DDX3 for their replication, other viruses inhibit DDX3's newly identified function in innate antiviral signalling. This review discusses the role of DDX3 in antiviral immunity and its inhibition or exploitation by different viruses.
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Martina Schröder (2011) conducted a review in Viral infection (HIV, HCV). DDX3 was evaluated. Human DDX3 is utilized by HIV and HCV for viral replication, whereas other viruses inhibit its newly identified function in innate antiviral signaling.
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