Key result
In patients undergoing laparoscopic resection for colorectal cancer within a fast-track regimen, five-year overall survival was similar between patients >75 years (66%) and <75 years (69%, p=0.9).
Why the study?
Does laparoscopic resection within a fast-track regimen yield comparable oncologic outcomes in elderly patients (>75 years) compared to younger patients (<75 years) with non-metastatic colorectal cancer?
Cohort (n=55)
No
Does laparoscopic resection within a fast-track regimen yield comparable oncologic outcomes in elderly patients (>75 years) compared to younger patients (<75 years) with non-metastatic colorectal cancer?
Absolute Event Rate: 66% vs 69%
p-value: p=0.9
Laparoscopic surgery within a fast-track regimen yields comparable long-term oncologic outcomes in elderly and younger patients with non-metastatic colorectal cancer.
Supports offering laparoscopic fast-track resection to selected elderly patients; hypothesis-generating and requires randomized confirmation.
Introduction: Trials of laparoscopic surgery for colorectal cancer in elderly with co-morbidity are needed.The aim of the present study was to evaluate the oncologic outcome after laparoscopic resection for non-metastatic colorectal cancer within a fast-track regimen comparing patients > 75 years of age to patients < 75 years of age.Methods: A total of 55 patients were laparoscopically operated upon for non-metastatic colorectal cancer in February 2001-March 2003.Twenty-nine patients were > 75 years old and 26 were younger.All patients had a perioperative fasttrack regimen.They were followed up for median 60 months.Results: The two age groups were comparable with regard to sex distribution, operative procedures and cancer stage.The co-morbidity (ASA score) was higher in the elderly group (p=0.05) as well as the perioperative complication rate, 24 vs. 15% (p=0.3).The five-year overall survival was 66% in the elderly group vs. 69% in the younger group (p=0.9).The disease-free survival was 62 vs.69%, respectively (p=0.1).The recurrence rate was 7 vs. 19%, respectively (p=0.2).For all the patients together the recurrence rate was 13% with no significant differences between the stage groups (p=0.4).Conclusion: Laparoscopic surgery and fast-track regimen together seem to have a beneficial effect on long-term oncologic outcome in the elderly.
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Bulut et al. (2010) conducted a cohort in Non-metastatic colorectal cancer (n=55). Age > 75 years vs. Age < 75 years was evaluated on Five-year overall survival (p=0.9). In patients undergoing laparoscopic resection for colorectal cancer within a fast-track regimen, five-year overall survival was similar between patients >75 years (66%) and <75 years (69%, p=0.9).
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