Key result
Productive schizophrenia is linked to ~3-fold higher CBF vs non-productive schizophrenia.
Why the study?
Variations in cerebral blood flow and oxidative metabolism in distinct types of schizophrenia and their correlation with mental state were not well characterized.
Population
55 patients with schizophrenia divided into three clinical symptom groups
Comparison
Patients with schizophrenia groups vs healthy young men
Design
Cross-sectional study
Authors
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CBF differences by schizophrenia subtype warrant cautious interpretation; leaves open links to cardiovascular risk or therapeutic targets.
Cross-Sectional (n=55)
Cerebral blood flow and oxidative metabolism vary significantly among different clinical subtypes of schizophrenia, correlating with the mental state of the psychosis.
Høyer et al. (2010) conducted a cross-sectional in Schizophrenia (n=55). Schizophrenia clinical symptom type vs. Healthy young men and other schizophrenia subtypes was evaluated on Total cerebral blood flow (CBF) and rates of cerebral oxygen, carbon dioxide, glucose and lactate metabolism. Patients with productive schizophrenia showed significantly increased cerebral blood flow (101.4 ml/100 g min), whereas non-productive schizophrenia showed significant decreases (36.7 ml/100 g min).
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