Key result
The combination of clomipramine, phenelzine, and chlorpromazine resulted in a catastrophic illness characterized by hyperpyrexia, blood pressure lability, tachycardia, renal failure, and coma.
Case Report (n=1)
The combination of clomipramine, phenelzine, and chlorpromazine can cause a catastrophic illness that may be reversed with dantrolene sodium.
Alerts to avoid this drug combination due to catastrophic risk; case report leaves dantrolene reversal open.
AbstractA young man developed a catastrophic illness after his first dose of clomiramine while taking phenelzine and chirpromazine. Striking findings were temperature of 110°F, blood pressure lability, tachycardia, renal failure, and coma. Dantrolene sodium was associated with reversal of his illness. Discussion centers on differential diagnosis of the patient's illness, a brief review of the pertinent literature, and recommendations for the transfer of patients from monoamine oxidase inhibitors to tri-cyclic antidepressants.
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Stern et al. (1992) conducted a case report in Catastrophic illness (hyperpyrexia, blood pressure lability, tachycardia, renal failure, coma) (n=1). Combination of clomipramine, phenelzine, and chlorpromazine was evaluated on Catastrophic illness. The combination of clomipramine, phenelzine, and chlorpromazine resulted in a catastrophic illness characterized by hyperpyrexia, blood pressure lability, tachycardia, renal failure, and coma.
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