The interaction between tranylcypromine and clomipramine can lead to a fatal hyperpyrexial reaction and disseminated intravascular coagulation.
In spite of intensive therapy, an otherwise fit 34-year-old man died following the hyperpyrexial reaction to an interaction between tranylcypromine and clomipramine. There was no evidence of drug overdose, but severe disseminated intravascular coagulation developed which proved fatal.
No takes yet. Share an insight, caveat, or question.
TACKLEY et al. (1987) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: