Key result
An overdose of 450 mg of amitriptyline in a 59-year-old male caused ventricular repolarization disorders and chest pain mimicking an acute myocardial infarction, despite angiographically normal coronary arteries.
Why the study?
Cardiovascular toxicity is common in tricyclic antidepressant overdoses, but myocardial infarction is rare; this report describes a case resulting in acute coronary syndrome.
Case Report (n=1)
Tricyclic antidepressant overdose can mimic acute myocardial infarction, presenting with chest pain, ECG repolarization abnormalities, and elevated troponin despite normal coronary arteries.
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Warrants vigilance for ACS in TCA overdose; hypothesis-generating for non-obstructive mechanisms and requires prospective confirmation before practice change.
Zerhoudi et al. (2022) conducted a case report in Tricyclic antidepressant overdose mimicking myocardial infarction (n=1). Amitriptyline overdose was evaluated on Clinical presentation and ECG changes. An overdose of 450 mg of amitriptyline in a 59-year-old male caused ventricular repolarization disorders and chest pain mimicking an acute myocardial infarction, despite angiographically normal coronary arteries.
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