Why the study?
Does intravenous physostigmine reverse malignant arrhythmias and conduction defects in a patient with amitriptyline poisoning?
Does intravenous physostigmine reverse malignant arrhythmias and conduction defects in a patient with amitriptyline poisoning?
Physostigmine may be effective in reversing severe cardiotoxic properties, including malignant arrhythmias and conduction defects, caused by amitriptyline overdose.
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Physostigmine reversed amitriptyline-induced VT and AV dissociation in one case; hypothesis-generating and should not yet change practice.
Jonathan M. Tobis (1976) studied this question.