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Self-poisoning with tricyclic antidepressants like amitriptyline and nortriptyline can lead to transient ECG changes and myocardial necrosis.
Two cases of self-poisoning with amitriptyline and one with nortriptyline are described. The patients showed transient E.C.G. changes and two had a rise in the serum enzymes usually associated with myocardial necrosis.
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Brackenridge et al. (1968) studied this question.
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