T-Rosette-Forming Cells, Cellular Immunity and Cancer

Development of accurate methods for enumeration of T and B lymphocytes in human peripheral blood during the past three years1 has led to a plethora of papers on T and B cells in various pathologic states. Just as B cells can be subdivided on the basis of surface immunoglobulins into various subpopulations, T-cell subpopulations with differing biologic properties almost certainly exist,2 perhaps some responsible for production of one or more mediators of cellular immunity, another for homograft rejection, a third for DNA synthesis in response to antigen or mitogen, and still another for cytotoxicity against tumor cells. The most widely . . .