Interrupted Aortic Arch in Two Siblings

Buch, J., Wennevold, A., Efsen, F. and Andersen, G. E. (Cardiovascular Laboratory of Medical Department B, Cardiovascular Section of Department of Diagnostic Radiology X and Department of Neonatology, Rigshospitalet, Copenhagen, Denmark). Interrupted aortic arch in two siblings. Acta Paediatr Scand, 69: 783, 1980.—Two siblings with identical malformations consisting of complete interruption of the aortic arch, type B, ventricular septa) defect, patent ductus arteriosus and anomalous origin of the right subclavian artery are described. Five other unrelated patients with interrupted aortic arch have been investigated in the years 1971–79. Of their 6 siblings, one had a coarctation of the aorta, while 5 were normal. Together with future reports this may help us to elucidate the genetics of this entity and may improve genetic counselling.