Key result
CABG achieves successful revascularization across 6 family members with severe inherited CAD.
Why the study?
Coronary artery bypass graft (CABG) is rare in several members of the same family despite known familial risk factors for coronary artery disease (CAD).
Case Report (n=6)
No
This case series highlights a rare familial clustering of severe coronary artery disease requiring CABG in six members of the same family, suggesting a strong genetic influence.
May prompt family screening for premature CAD; leaves open identification of causative genetic variants.
Coronary artery disease (CAD) is a multifactorial problem. Although hyperlipidemia (HLP), diabetes (DM), and hypertension (HTN) are known as the familial and cardiac risk factors, CABG is rare in the several members of a family. We reported the six members of a family who presented with MI and/or advanced angina pectoris during the 6 years. CABG(Coronary artery bypass graft) considered for all patients due to involvement in main coronary arteries and clinical presentation. The ejection fraction (EF) was varied between 25% to 70%. Beating heart cardiopulmonary bypass (beating heart CPB) and off-pump were chosen as surgical method. The mean duration of surgery was about 4 hours. The only post-operative complication was deep wound infected in a young man who was smoker and drug abuser. According to family relationship of patients and the high effect of genetic penetration, we presume the gene influence to incidence CAD and potential to undergoing CABG, in members of a special family.
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Alizadeh et al. (2018) conducted a case report in Coronary Artery Disease (n=6). Coronary Artery Bypass Graft (CABG) was evaluated on Surgical outcomes and post-operative complications. Six members of the same family successfully underwent coronary artery bypass grafting for severe coronary artery disease, highlighting a strong familial and genetic predisposition.
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