Key result
Levamisole induces reversible p-ANCA and lupus anticoagulant-associated cutaneous necrosis in factor V Leiden heterozygosity.
Why the study?
Cutaneous necrosis associated with levamisole treatment in a child heterozygous for factor V Leiden and formation of p-ANCA and lupus anticoagulant is not well characterized.
Does long-term levamisole treatment cause cutaneous necrosis in a child heterozygous for factor V Leiden?
Comparison
Long-term levamisole treatment vs treatment cessation
Design
Case report
Authors
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May warrant caution with levamisole in factor V Leiden carriers; single case leaves open causality.
Does long-term levamisole treatment cause cutaneous necrosis in a child heterozygous for factor V Leiden?
Levamisole treatment can induce cutaneous necrosis associated with p-ANCA and lupus anticoagulant, which is reversible upon discontinuation.
Powell et al. (2002) studied this question. Levamisole treatment in a child heterozygous for factor V Leiden induced cutaneous necrosis associated with p-ANCA and lupus anticoagulant, which resolved when the drug was stopped.
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