Answers are grounded in this paper and cite their sources.
A simple and convenient method for the synthesis of carbon‐14 labeled diphenylhydantoin (DPH) (I) and its major metabolite 5‐(p‐hydroxyphenyl)‐5‐phenylhydantoin (HPPH) (II) in 70 minutes is described. This synthesis allows incorporation of carbon‐11‐11 (physical half‐life 20 minutes) into these molecules. Incorporation of short‐lived isotopes into drug molecules provides a vastly expanded potential for study of in vivo distribution of drugs and development of tumor specific agents.
No takes yet. Share an insight, caveat, or question.
Stavchansky et al. (1974) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: