Key result
Co-expression of KV11.1 with PKD1 reduced current amplitudes, and ablation of the putative PKD phosphorylation site (S284A) increased maximal current, identifying S284 as a main PKD target.
PKD1 mediates PKC effects on the KV11.1 potassium channel by targeting the S284 residue in the N-terminus, reducing current amplitudes.
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May alter cardiac repolarization susceptibility; leaves open whether PKD1-S284 targeting affects arrhythmia risk in vivo.
Steffensen et al. (2018) studied this question. Co-expression of KV11.1 with PKD1 and S284A mutation was evaluated on KV11.1 current amplitudes and phosphorylation sites. Co-expression of KV11.1 with PKD1 reduced current amplitudes, and ablation of the putative PKD phosphorylation site (S284A) increased maximal current, identifying S284 as a main PKD target.
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