Key result
High-dose simvastatin is associated with an increased risk of rhabdomyolysis.
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Pamela Wratchford, M.D., Charles D. Ponte, PHARM.D., CDE, BCPS, BC-ADM, FASHP, FCCP, FAPhA; High-dose simvastatin and rhabdomyolysis, American Journal of H
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Wratchford et al. (2003) studied this question. High-dose simvastatin therapy is associated with the development of rhabdomyolysis.
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