Key result
Delayed rectifier deactivation and inward rectifier currents govern diastolic excitability and subthreshold response dynamics.
Why the study?
The ionic mechanisms underlying slow recovery of cardiac excitability and rate-dependent activation failure in ventricular myocytes were not fully understood.
Population
Single enzymatically dissociated guinea pig ventricular myocytes
Design
Experimental study with computer simulations using modified Beeler and Reuter model
Authors
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No immediate change to arrhythmia management; leaves open translation of these ionic mechanisms to clinical risk or therapy.
Delmar et al. (1989) studied Wenckebach phenomenon and cardiac excitability. Experimental measurements and computer simulations was evaluated on Ionic mechanisms of slow recovery of cardiac excitability and rate-dependent activation failure. Slow deactivation of the delayed rectifier current determines variations in excitability during diastole, while the inward rectifier current determines the subthreshold response amplitude and shape.
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