Key result
LV wall motion drives diastolic vortex formation across varied simplified mitral valve models.
Why the study?
Standard imaging tools do not provide quantitative insight into cardiac fluid dynamics phenomena such as left ventricle fluid dynamics with mitral regurgitation.
A novel computational modeling approach using fictitious elastic structure regularization enables detailed simulation of left ventricular fluid dynamics and mitral regurgitation from cardiac MRI data.
May simplify LV flow modeling from cardiac MRI; leaves open prospective validation before clinical use.
Computer modeling can provide quantitative insight into cardiac fluid dynamics phenomena that are not evident from standard imaging tools. We propose a new approach to modeling left ventricle fluid dynamics based on an image-driven model-based description of ventricular motion. In this approach, the end-diastolic geometry and time-dependent deformation of the left ventricle cavity are obtained from cardiac magnetic resonance images and a fictitious elastic structure is used to impose the contractile behavior of the left ventricle. This allows seamless treatment of the isovolumic phases. Besides the ventricular motion, the intracavitary fluid dynamics is controlled by the mitral valve. Three different mitral valve models are included in the simulation: an idealized diode (with or without regurgitation) and a lumped parameter model accounting for the opening dynamics of the valve and including regurgitation.
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Lassila et al. (2017) studied Mitral regurgitation (n=1). Computational fluid dynamics simulation with three mitral valve models was evaluated on Diastolic flow patterns and regurgitant volume. Simulations using three different simplified mitral valve models produced qualitatively similar diastolic flow patterns, indicating that left ventricular vorticial flow can be simulated primarily from wall motion.
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