Key result
Mitochondrial T16189C polymorphism linked to ~2-fold higher odds of coronary artery disease.
Why the study?
The mitochondrial T16189C polymorphism has been suspected to associate with multifactorial diseases, but its relationship with coronary artery disease in Middle European populations was unclear.
Is the mitochondrial T16189C polymorphism associated with coronary artery disease and type 2 diabetes mellitus in a Middle European population?
Case-Control (n=2,468)
Yes
Is the mitochondrial T16189C polymorphism associated with coronary artery disease and type 2 diabetes mellitus in a Middle European population?
Odds Ratio: 2.05 (95% CI 1.6–2.7)
Absolute Event Rate: 21.6% vs 11.8%
p-value: p=<0.0000001
The mitochondrial T16189C polymorphism is significantly associated with coronary artery disease in a Middle European population, independent of age, sex, and BMI.
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Mueller et al. (2011) conducted a case-control in Coronary Artery Disease and Type 2 Diabetes Mellitus (n=2,468). Mitochondrial T16189C polymorphism vs. Healthy controls was evaluated on Prevalence of T16189C polymorphism (OR 2.05, 95% CI 1.6-2.7, p=<0.0000001). The mitochondrial T16189C polymorphism was significantly more prevalent in patients with coronary artery disease compared to healthy controls (21.6% vs 11.8%, OR 2.05).
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