A series of N-unsubstituted 1,2,4-triazol-3-ylpyridines was prepared for antiarthritic testing. Weak and scattered antiinflammatory activity was observed, with no clear structure-activity relationships. Some of the compounds, notably the 5-pyridyl-1,2,4-triazole-3-carboxylic acids, showed infrared bands characteristic of strong hydrogen bonding.
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EJ Browne (1975) studied this question.
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