Key result
Therapeutic plasma exchange aids neurological recovery in pediatric severe enterovirus-associated acute cerebellitis.
Why the study?
Acute cerebellitis is a rare complication of pediatric infections, and the role of therapeutic plasma exchange in enterovirus-associated cases is not well established.
Does therapeutic plasma exchange improve outcomes in pediatric enterovirus-associated acute cerebellitis?
Case Report (n=1)
Does therapeutic plasma exchange improve outcomes in pediatric enterovirus-associated acute cerebellitis?
Therapeutic plasma exchange may be an effective rescue therapy for severe pediatric enterovirus-associated acute cerebellitis unresponsive to IVIG.
May support therapeutic plasma exchange as rescue therapy in refractory pediatric enterovirus cerebellitis; leaves open confirmation in controlled trials.
BACKGROUND: Acute cerebellitis is a rare complication of pediatric infections. There are many reports that viral infections lead to neurological manifestations, including acute cerebellitis. METHODS: A retrospective chart review was conducted for pediatric patients diagnosed with enterovirus cerebellitis between 2000 and 2024. The methods involved reviewing clinical and radiological records and assessing the treatment methods. RESULTS: Case Report We present the case of a 4-year-old immunocompetent child who initially presented with acute encephalopathy followed by truncal ataxia, and eventually received a diagnosis of postinfectious cerebellitis. Enterovirus real-time polymerase chain reaction were positive in the nasopharyngeal swab. Therapeutic plasma exchange (TPE) was started due to neurological deterioration despite IVIG treatment. She improved significantly with TPE, and methylprednisolone treatment and was discharged in good health status. The patient is being followed up as neurologically normal. CONCLUSION: Acute cerebellitis associated with enterovirus is a rare pediatric disorder. Early diagnosis and treatment with TPE in this severe case is thought to be preventive for the potentially fatal complications.
No takes yet. Share an insight, caveat, or question.
Akçay et al. (2024) conducted a case report in Acute cerebellitis due to enterovirus (n=1). Therapeutic plasma exchange (TPE) was evaluated on Neurological improvement. Therapeutic plasma exchange led to significant neurological improvement in a 4-year-old child with severe enterovirus-associated acute cerebellitis.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: