New developments in personalised medicine pose a technological challenge for the implementation of diagnostic devices demanding an increase for the speed, throughput and sensitivity for the detection of proteomic biomarkers.Following the tracks of genetics where the progress came through the analysis of DNA fragments, peptides, which are small fragments of proteins, can provide a new tool to get insights into the analysis of macromolecules.However, the current methods of combinatorial chemistry and sensing based on liquid handling and labelling, respectively, cannot cope with the demands of throughput and speed required by clinical applications.Nanotechnology holds promises to improve in-situ synthesis of microarrays and label free sensing to provide the combinatorial flexibility, quickness and sensitivity to help for the implementation of proteomic diagnosis in precision medicine.
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García et al. (2019) studied this question.
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