Key result
5-ASA triggers reversible and rechallenge-confirmed acute pericarditis in a young patient with ulcerative colitis.
Why the study?
Acute pericarditis as a hypersensitive reaction to 5-aminosalicylic acid treatment in severe active ulcerative colitis is not well characterized.
Case Report (n=1)
No
5-ASA can cause a hypersensitivity reaction manifesting as acute pericarditis in patients with ulcerative colitis, which resolves upon discontinuation and recurs upon rechallenge.
5-ASA may induce pericarditis in young UC patients; this Level 5 case leaves open incidence and causality questions.
A 17-year-old male who had been diagnosed with ulcerative colitis was prescribed 80 mg prednisolone and 1,500 mg 5-aminosalicylic acid (5-ASA) per day. Two weeks after initiating therapy, he was referred to our hospital for evaluation of chest pain and high fever. Electrocardiography (ECG) showed ST elevation in limb and precordial leads. Chest pain with high fever and ECG changes were resolved after 5-ASA was discontinued. Three weeks later, the administration of a low dose of 5-ASA was associated with the immediate recurrence of pericarditis associated with chest pain, suggesting a hypersensitive reaction to 5-ASA in this patient.
No takes yet. Share an insight, caveat, or question.
Imamura et al. (2001) conducted a case report in Severe active ulcerative colitis (n=1). 5-aminosalicylic acid (5-ASA) was evaluated on Development of acute pericarditis. Treatment with 5-ASA in a 17-year-old male with ulcerative colitis induced acute pericarditis that resolved upon discontinuation and recurred upon re-challenge.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: