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Atrial fibrosis and ionic remodeling during heart failure decrease Ito, ICa, and IK currents, establishing a primary mechanistic substrate for atrial fibrillation. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

October 11, 2007Circulation ResearchOpen Access

Mounting Evidence That Fibrosis Generates a Major Mechanism for Atrial Fibrillation

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Key result

Atrial fibrosis and ionic remodeling during experimental heart failure decrease Ito, ICa, and IK currents, generating a major mechanism for atrial fibrillation.

Design

Editorial

Authors

MSMadison S. SpachPediatric / Congenital Cardiology

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Implication

This editorial discusses the mounting evidence that fibrosis and atrial ionic remodeling are major mechanisms underlying atrial fibrillation.

Key Points

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Cite This Study

Madison S. Spach (2007) studied this question. Atrial fibrosis and ionic remodeling during experimental heart failure decrease Ito, ICa, and IK currents, generating a major mechanism for atrial fibrillation.

synapsesocial.com/papers/6ab9af93862dfad8e9884fa0 https://doi.org/10.1161/circresaha.107.163956

Topics

Heart failure HFrEF treatment Atrial fibrillation Persistent AF management AF ablation outcomes

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Implication

This editorial discusses the mounting evidence that fibrosis and atrial ionic remodeling are major mechanisms underlying atrial fibrillation.

Mounting Evidence That Fibrosis Generates a Major Mechanism for Atrial Fibrillation

Discussion

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Implication

Key Points

Cite This Study

Topics

Mounting Evidence That Fibrosis Generates a Major Mechanism for Atrial Fibrillation

Discussion

Member takes

Implication

Key Points

Cite This Study

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