Key result
Medical therapy alone yields ~32% 10-year survival in nonischemic dilated cardiomyopathy, tied to QRS duration.
Why the study?
Most studies have focused on short and medium-term survival in nonischemic dilated cardiomyopathy patients, with limited data on long-term survival and LVEF changes.
Cohort (n=127)
Nearly one-third of patients with nonischemic dilated cardiomyopathy survive over 10 years on medical therapy alone, with narrow QRS duration predicting sustained LVEF recovery.
Long-term survival with LVEF recovery occurs in select nonischemic DCM patients on medical therapy; leaves open predictors of sustained remission for prospective validation.
A BSTRACT Background: Most studies have focussed on short and medium-term survival in dilated cardiomyopathy (DCM) patients. We aimed to study the profile and changes in left ventricular ejection fraction (LVEF) of nonischemic DCM patients who survived more than 10 years on medical management alone. Methods: This was a retrospective analysis of patients in the nonischemic DCM cohort recruited from April 2003 to January 2007 with LVEF ≤40%. All patients who survived at least 10 years from the initial DCM diagnosis and were on medical therapy alone were included in the study. Results: Forty of 127 (31.5%) patients survived over 10 years. Mean follow-up duration was 145.48 ± 16.8 months. Baseline left ventricular (LVEF) was 30.01 ± 7.89%. Of these, 26 (65%) patients showed recovery of LVEF. Eight (30.8%) of these had a relapse following initial recovery. 14 patients (35%) did not show improvement in LVEF. Multivariate analysis showed that only variable associated with sustained recovery of LVEF was shorter QRS duration with a mean QRS duration of 95.2 ± 11.3 ms versus 117.4 ± 22.6 ms in the two groups ( P < 0.001). Conclusions: 31. 5% of patients with nonischemic DCM survived more than 10 years with medical therapy alone. Almost two-thirds of these long-term survivors showed recovery of LVEF. Narrow QRS duration predicted sustained recovery of LVEF.
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Monga et al. (2022) conducted a cohort in Nonischemic dilated cardiomyopathy (n=127). Medical therapy alone was evaluated on Survival over 10 years. Medical therapy alone in patients with nonischemic dilated cardiomyopathy resulted in a >10-year survival rate of 31.5%, with narrow QRS duration predicting sustained LVEF recovery (P<0.001).
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