Key result
Patients with eosinophilic pneumonia had significantly higher levels of periostin, IL-13, and TGF-β1 in their bronchoalveolar lavage fluid compared to patients with idiopathic pulmonary fibrosis and sarcoidosis.
Observational (n=80)
Yes
Periostin levels are elevated in eosinophilic pneumonia and correlate with TGF-β1, suggesting a role in its pathogenesis.
May inform future diagnostic strategies in eosinophilic pneumonia; leaves open its pathogenic role and clinical utility.
BACKGROUND: Periostin is induced in bronchial epithelial cells and fibroblasts by various stimuli including interleukin (IL)13 and transforming growth factor (TGF)-β1, and is involved in allergic diseases such as asthma and atopic dermatitis, playing an important role in tissue remodeling and fibrosis. The role of periostin in the pathogenesis of eosinophilic lung diseases, however, is unclear. OBJECTIVE: To examine the contribution of periostin to eosinophilic inflammation of the lung in humans, we evaluated periostin, IL-13, and TGF-β1 levels in the bronchoalveolar lavage fluid (BALF) of patients with eosinophilic pneumonia (EP). METHODS: Periostin, IL-13, and TGF-β1 concentrations in the BALF were measured by enzyme-linked immunosorbent assay in patients with acute EP, chronic EP, idiopathic pulmonary fibrosis (IPF), and sarcoidosis. Further, we analyzed the relationship between periostin, IL-13, and TGFβ-1, levels and the number of inflammatory cells in the BALF. RESULTS: The absolute number of eosinophils, and the periostin, IL-13, and TGF-β1 levels in the BALF were significantly higher in patients with EP than in patients with IPF and sarcoidosis. Concentrations of periostin significantly correlated with the concentrations of TGF-β1, but not those of IL-13, in the BALF of patients with EP. Periostin levels also significantly correlated with the absolute number of eosinophils in the BALF of patients with IPF, but not EP. CONCLUSIONS: Our findings suggest that TGF-β1 might increase the production of periostin in the lungs of patients with EP. Periostin might contribute the pathogenesis of not only EP, but also IPF.
No takes yet. Share an insight, caveat, or question.
Katoh et al. (2019) conducted an observational in Eosinophilic pneumonia (n=80). Eosinophilic pneumonia vs. Idiopathic pulmonary fibrosis and sarcoidosis was evaluated on Periostin levels in bronchoalveolar lavage fluid (ng/mL) (p=<0.05). Patients with eosinophilic pneumonia had significantly higher levels of periostin, IL-13, and TGF-β1 in their bronchoalveolar lavage fluid compared to patients with idiopathic pulmonary fibrosis and sarcoidosis.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: