Neuropsychotherapy Using Transactional Analysis With a Patient Affected by Cognitive Impairment Due to Organic Brain Damage: Reflections on the Model’s Adaptability Through a Clinical Case Study

Transactional analysis (TA) is a theoretical and clinical model applied across psychotherapy, counseling, education, and organizational contexts. This article presents a longitudinal, single-case study integrating clinical observation, neuropsychological assessment, and relational TA diagnosis. The aim of the article is to explore how a psychodynamic TA psychotherapy can support psychological and functional reorganization following neurological injury. The authors introduce a clinical-operational model—the cycle of relational neuroplasticity—to conceptualize how emotionally salient therapeutic processes may align with principles derived from relational neuroscience, without implying direct neurobiological causality. Through this case, the authors illustrate how TA psychotherapy, when responsive to cognitive and emotional constraints, can remain clinically viable and meaningful in the presence of neurological damage. Overall, the study highlights how TA’s relational structure can be integrated within a neuropsychotherapeutic framework, thereby contributing to the dialogue between psychotherapy and neuroscience and offering clinically grounded insights relevant to neurorehabilitation contexts.