Evaluating Risk of Tuberculosis Infection and Disease Among Adolescents Who Are HIV-exposed Uninfected in Botswana

This Botswana-based study evaluated the prevalence of tuberculosis (TB) infection and disease among 50 adolescents, including 25 HIV-exposed uninfected (HEU) and 25 HIV-unexposed uninfected. We found that 12% of adolescents HEU had a positive QuantiFERON-TB Gold Plus test, while no adolescent HIV-unexposed uninfected tested positive. This exploratory study found that adolescents HEU may be at increased risk for TB infection and disease, with larger studies needed.