Key result
Review outlines PFA safety, procedural complications, and current knowledge gaps for atrial and ventricular arrhythmias.
Why the study?
A precise understanding of the safety profile of pulsed field ablation for atrial and ventricular arrhythmias is essential as clinical experience expands.
What is the safety profile and what are the complications associated with pulsed field ablation for atrial and ventricular arrhythmias?
What is the safety profile and what are the complications associated with pulsed field ablation for atrial and ventricular arrhythmias?
This review provides a comprehensive overview of the safety profile of pulsed field ablation, distinguishing between procedure-related and electroporation-specific complications.
Captured external expert commentary on this paper, strongest first. Original sources are linked where available.
“With PFA, for example, it seems to lead to faster procedures and it may increase patient safety—but are we sure it is not creating new problems? It is true we will not be up all night worrying about esophageal perforations, but do we now need to worry about hemolysis? What about brain lesions? I just think we will probably have some tamping down of enthusiasm as we start to explore more of those things.”
“Every new energy source comes with its own learning curve. Understanding electric field dynamics, dosing strategies and system-specific safety profiles is critical to optimizing patient outcomes and avoid unintended consequences.”
“Pulsed field ablation represents a fundamental shift in catheter ablation technology. Given the rapid pace of adoption and the evolving clinical data, this statement helps clinicians interpret current evidence and implement PFA thoughtfully.”
Pulsed field ablation warrants targeted surveillance for electroporation-specific risks; leaves open long-term safety data needs across arrhythmia applications.
Pulsed field ablation (PFA) has rapidly emerged as an important ablation technology for atrial arrhythmias and is increasingly being explored for ventricular arrhythmias. As clinical experience expands, a precise understanding of its safety profile is essential. This review summarizes contemporary evidence on the safety of PFA, distinguishes procedure-related complications from those attributable to electroporation, and highlights areas in which evidence remains limited.
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Cecco et al. (2026) conducted a review in Atrial and ventricular arrhythmias. Pulsed field ablation (PFA) was evaluated. Pulsed field ablation is an emerging technology for atrial and ventricular arrhythmias whose safety profile, procedure-related complications, and knowledge gaps are summarized in this review.
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