Persistent ileal ulcerations in Crohn's disease (CD) typically suggest refractory inflammation, yet rare fungal infections may coexist silently. We report a 22-year-old immunocompetent man with CD and seronegative spondyloarthritis who achieved clinical remission on ustekinumab but exhibited persistent ileal ulcerations. Repeat biopsies revealed Histoplasma spp . on Periodic Acid–Schiff staining, confirming intestinal histoplasmosis without pulmonary involvement. Dual pathology required continuation of ustekinumab and initiation of itraconazole. This case highlights the importance of considering fungal infections when endoscopic healing fails despite clinical response.
No takes yet. Share an insight, caveat, or question.
Oliva et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: