Key result
Low adiponectin levels are linked to a ~3.4-fold higher risk of pediatric metabolic syndrome.
Why the study?
The pathophysiological mechanism linking obesity to early atherosclerosis in children is poorly understood.
Are low serum adiponectin levels associated with metabolic syndrome and early atherosclerosis in obese children?
Observational (n=264)
Are low serum adiponectin levels associated with metabolic syndrome and early atherosclerosis in obese children?
Relative Risk: 3.43
Low serum adiponectin levels (<7060 ng/ml) in children are significantly associated with an increased risk of metabolic syndrome and early surrogate markers of atherosclerosis.
Adiponectin was associated with metabolic syndrome and vascular markers in obese children; leaves open its role as biomarker or target.
BACKGROUND: The atherosclerotic process starts at an early age and is linked to obesity. However, the exact pathophysiological mechanism is poorly understood. OBJECTIVE: To investigate the relationship between serum adiponectin and metabolic syndrome and early arteriosclerosis. SUBJECTS: 176 obese and 88 normal children. METHODS: Ultrasound measurement was performed to investigate IMT, FMD, carotid artery compliance (CAC). Adiponectin was measured by enzyme-linked immunosorbent assay. RESULTS: Adiponectin levels correlated negatively with obese markers, blood pressure, fasting insulin, high sensitive CRP, HOMA-IR and IMT; marginally positively associated with CAC and HDL-c. The risk of metabolic syndrome increased 3.43 times when adiponectin levels were less than 7060 ng/ml. Heavy obesity, hypertension, low HDL-c, fasting hyperinsulin, High LDL-c and metabolic syndrome percentage were different in three groups according to the cut-off value of adiponectin. CONCLUSIONS: Low adiponectin levels are associated with a high incidence of metabolic syndrome.
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Liang et al. (2010) conducted an observational in Obesity and Metabolic Syndrome (n=264). Low serum adiponectin levels (<7060 ng/ml) vs. Higher serum adiponectin levels (≥7060 ng/ml) was evaluated on Metabolic syndrome (3.43 times increased risk). Low serum adiponectin levels (<7060 ng/ml) were associated with a 3.43-fold increased risk of metabolic syndrome and correlated negatively with carotid intima-media thickness in children.
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