Key result
Exercise enhances fibrinolysis ~64% by shortening ECLT, but paced tachycardia shows no effect.
Why the study?
The contribution of heart rate changes to the increase in fibrinolytic activity associated with exercise was unclear.
Does increased heart rate via pacing or exercise alter plasma fibrinolytic activity in patients with pacemakers and healthy volunteers?
Population
9 patients with dual chamber cardiac pacemakers and 7 volunteers
Comparison
Stimulated tachycardia to 123 beats/min vs baseline and submaximal exercise to 90% target heart rate and 120 beats/min vs baseline
Design
Experimental study measuring fibrinolytic activity before and after interventions
Follow-up
10 minutes of stimulated tachycardia or post-exercise
Authors
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Exercise enhances fibrinolysis independently of heart rate; hypothesis-generating for mechanisms in paced patients.
Does increased heart rate via pacing or exercise alter plasma fibrinolytic activity in patients with pacemakers and healthy volunteers?
Changes in heart rate alone do not contribute to the increase in fibrinolytic activity associated with exercise.
Gough et al. (1992) studied Patients with dual chamber cardiac pacemakers (n=16). Pacemaker-stimulated tachycardia and exercise vs. Baseline was evaluated on Plasma fibrinolytic activity (ECLT, t-PA:Ag, PAI, PAI-1:Ag). Submaximal exercise reduced median ECLT from 248 to 90 min (P<0.01), but pacemaker-stimulated tachycardia caused no significant change (225 vs 200 min), showing heart rate alone is not responsible.
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