What question did this study set out to answer?

To determine whether the balance between blood clotting and clot-dissolving systems is maintained during acute strenuous exercise and post-exercise recovery.

December 1, 1995European Heart Journal

Unbalanced haemostatic changes following strenuous physical exercise

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Why the study?

Does strenuous physical exercise alter the balance of coagulant and fibrinolytic activity in sedentary males?

Population

29 sedentary males (20-30 years)

Design

Other

Follow-up

25 min recovery

Authors

PBP.J.M. van den BurgSanquin JHJ.E.H. HospersInstitut National de la Recherche Agronomique MVMarja van VlietPositive Action

Discussion

Member takes

Implication

May heighten post-exercise CV risk in sedentary males; hypothesis-generating for prevention trials.

Key Points

To determine whether the balance between blood clotting and clot-dissolving systems is maintained during acute strenuous exercise and post-exercise recovery.
Subjected 29 sedentary males aged 20-30 years to a standardized cycle ergometer test.
Collected blood samples at 70% VO2max (submaximal), 100% VO2max (maximal), and throughout 25 minutes of recovery to assess coagulant factors and fibrinolytic markers, adjusting for plasma volume shifts.
Submaximal and maximal exertion triggered parallel rises in clotting factors (factors VIII and IX) and fibrinolytic activity (tissue-type plasminogen activator antigen and activity, alongside urokinase-type plasminogen activator antigen).
After adjusting for plasma volume changes, factor VII:c elevation reversed, while factor XII:c and fibrinogen showed no significant exercise-induced alterations.
Coagulant potential remained elevated during the 25-minute recovery phase, whereas fibrinolytic potential dropped sharply, creating an unbalanced prothrombotic state.

Structured PICO

Does strenuous physical exercise alter the balance of coagulant and fibrinolytic activity in sedentary males?

Population

29 sedentary males (20-30 years)

Intervention

Standardized cycle ergometer test at two exercise levels: 70% VO2max (submaximal) and 100% VO2max (maximal)

Outcome

Changes in coagulant and fibrinolytic potential (tissue type plasminogen activator antigen, urokinase plasminogen activator antigen, tissue type plasminogen activator activity, clotting activity of factors VII, VIII, IX, XII, fibrinogen, and activated partial thromboplastin time)surrogate

Strenuous exercise in sedentary individuals leads to a prothrombotic state during recovery, which may explain the increased risk of exercise-related cardiovascular events.

Cite This Study

Burg et al. (1995) studied this question.

synapsesocial.com/papers/6a981c4db845b435affa9999 https://doi.org/10.1093/oxfordjournals.eurheartj.a060859

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Unbalanced haemostatic changes following strenuous physical exercise

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Unbalanced haemostatic changes following strenuous physical exercise

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider