Key result
LVEF <40% is linked to ~39% higher odds of abnormal heart rate turbulence in CAD.
Why the study?
The association between heart rate turbulence parameters and clinical characteristics in coronary artery disease patients was evaluated to understand influencing factors.
What clinical characteristics are associated with abnormal heart rate turbulence in patients with coronary artery disease?
Observational (n=122)
What clinical characteristics are associated with abnormal heart rate turbulence in patients with coronary artery disease?
Effect estimate: OR 1.27 (age > 60 years); OR 1.39 (EF < 40%)
p-value: p=0.002 (age > 60); 0.001 (EF < 40%)
Advanced age, prior myocardial infarction, and left ventricular dysfunction are independent clinical predictors of abnormal heart rate turbulence in patients with coronary artery disease.
May flag higher-risk CAD patients for monitoring; leaves open incremental prognostic value beyond standard factors.
BACKGROUND: The aim of this study is to evaluate the association between heart rate turbulence (HRT) parameters and clinical characteristics of coronary artery disease (CAD) patients. METHODS AND RESULTS: In 122 patients (mean age 62 +/- 9 years) with angiographically documented CAD, 24-hour Holter monitoring with HRT analysis was performed to evaluate turbulence onset (TO) and turbulence slope (TS). There was a significant correlation between TO and TS (P =-0.31; P < 0.001). According to quartile values, TO >or=-0.37% and TS 60 years (OR 1.27; P = 0.002) and EF < 40% (OR 1.39; P = 0.001) as independent clinical factors associated with abnormal HRT parameters. CONCLUSIONS: HRT parameters are influenced by clinical characteristics and pharmacotherapy of studied patients with TS more than abnormal TO depending on clinical characteristics of patients. Advanced age, prior myocardial infarction and left ventricular dysfunction are key factors influencing values of HRT parameters.
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Cygankiewicz et al. (2003) conducted an observational in Coronary artery disease (CAD) (n=122). Clinical characteristics (advanced age, left ventricular dysfunction) was evaluated on Abnormal heart rate turbulence (HRT) parameters (OR 1.27 (age > 60 years); OR 1.39 (EF < 40%), p=0.002 (age > 60); 0.001 (EF < 40%)). Advanced age >60 years (OR 1.27, P=0.002) and left ventricular ejection fraction <40% (OR 1.39, P=0.001) were independently associated with abnormal heart rate turbulence in coronary artery disease.
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