Key result
Higher sTNFR2 levels are independently linked to increased arterial stiffness in nonobese type 2 diabetes.
Why the study?
Other factors beyond typical risk factors appear to contribute to the progression of atherosclerosis in type 2 diabetic patients, necessitating investigation of novel associations.
Is soluble tumor necrosis factor receptor 2 associated with brachial-ankle pulse-wave velocity in nonobese Japanese type 2 diabetic patients?
Cross-Sectional
Is soluble tumor necrosis factor receptor 2 associated with brachial-ankle pulse-wave velocity in nonobese Japanese type 2 diabetic patients?
Soluble Tumor Necrosis Factor Receptor 2 is independently associated with brachial-ankle pulse-wave velocity, a marker of aortic stiffness, in nonobese Japanese patients with type 2 diabetes.
Supports TNF pathway research in diabetic vascular disease; hypothesis-generating and should not yet change practice.
Type 2 diabetes is associated with high mortality and morbidity due to atherosclerosis. Biermen (1) estimated that typical risk factors, including blood pressure, cholesterol, and smoking, can account for no more than 30% of excess cardiovascular risk factor in diabetic patients. Thus, other factors seem to play a role in the progression of atherosclerosis in diabetes. Aortic stiffness measured by pulse- wave velocity (PWV) is shown to be highly predictive of cardiovascular mortality in type 2 diabetic patients (2). While age and blood pressure are shown …
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Ohgushi et al. (2006) conducted a cross-sectional in Type 2 diabetes. Soluble Tumor Necrosis Factor Receptor 2 was evaluated on Brachial-Ankle Pulse-Wave Velocity. Soluble Tumor Necrosis Factor Receptor 2 is independently associated with brachial-ankle pulse-wave velocity in nonobese Japanese patients with type 2 diabetes.
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