Key result
Altered His bundle conductivity produces three distinct conduction regimes in a cardiac electrical model.
Why the study?
The mechanisms of impulse distribution, delay, and block in the heart's electrical conduction system, particularly bundle branch block, require numerical modeling to understand conduction regimes.
Numerical modeling of the heart's electrical conduction system demonstrates that varying conductivity can result in normal excitation, delayed excitation, or complete bundle branch block.
Answers are grounded in this paper and cite their sources.
Modeling of His conduction regimes should not change practice; leaves open experimental validation of sodium channel-driven delay in conduction disease.
In the article the excitatory irradiation in the electrical conduction system was numerically modeled. The overview of transmembrane potential of electrical conduction system was given. The Luo-Rudi model (2011) was chosen for the investigation. A finite element model of the electrical conduction system was built in which the latter was regarded as a one-dimensional sequence of cells connected at the edges. Based on the elaborated model one of the mechanisms of a bundle branch block was investigated. A Y-shaped structure which models the move from the common trunk of the bundle of His to the bundle branches was investigated. The results show that depending on the conductivity of certain parts of the electrical conduction system of the heart three regimes might occur: excitation advancing through branching, complete block or excitation advancing with delay. Conductivity Value Domains for the common trunk of the bundle of His and the bundle branches in which each of the regimes occurs were obtained. The role of quick and slow sodium channels when the regime with delay occurs is considered
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Vasserman et al. (2018) studied Bundle branch block. Computational modeling of conductivity variation was evaluated on Excitation propagation regimes. Numerical modeling of the heart's electrical conduction system demonstrated that varying conductivity in the bundle of His results in three regimes: normal propagation, complete block, or delayed propagation driven by slow sodium channels.
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