February 25, 2009Nephrology Dialysis Transplantation
Role of renal haemodynamics in the renal risks of overweight
Key result
Severe obesity is linked to a ~7-fold higher long-term risk of end-stage renal disease.
Why the study?
Renal damage is an emerging complication of weight excess, and the role of renal haemodynamics in this risk requires comprehensive review and clarification.
Population
Overweight and obese individuals with BMI > 25 and BMI > 30 kg/m2
Comparison
Renal haemodynamic profiles associated with different BMI categories
Design
Review article synthesizing recent studies and data
Authors
Discussion
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Implication
Supports renal hemodynamic monitoring in weight excess; leaves open whether targeted interventions alter long-term outcomes in trials.
Structured PICO
P
Population
Overweight and obese individuals (BMI > 25 and BMI > 30 kg/m2)
Weight excess, even in mild forms, induces unfavorable renal hemodynamic changes such as hyperfiltration and increased filtration fraction, which independently predict long-term renal damage.
Limitations
- The prognostic impact of a decrease in renal reserve after kidney donation remains unknown.
- There are controversies regarding the potential beneficial effects of sodium restriction in preventing renal disease.
Cite This Study
Krikken et al. (2009) conducted a review in Overweight, obesity, and renal damage. Weight excess (Overweight/Obesity) vs. Lean subjects was evaluated. A BMI over 40 kg/m2 is associated with a 7-fold increased long-term risk for end-stage renal disease compared to lean subjects, while a BMI over 25 kg/m2 carries a 3-fold elevated risk.