Key result
Insulin tolerance test glucose disappearance rate closely correlates with euglycemic clamp measurements in type 2 diabetes.
Why the study?
The validity of the plasma glucose disappearance rate (KITT) from the insulin tolerance test for evaluating insulin sensitivity in type 2 diabetes patients after insulin therapy was unclear.
Is the insulin tolerance test (ITT) a valid method for evaluating insulin sensitivity in patients with type 2 diabetes receiving insulin therapy?
Comparison
Insulin tolerance test (KITT) vs euglycemic clamp test (clamp-IR) in study 1
Design
Observational study with two arms including correlation analyses
Authors
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ITT correlation with clamp supports validity in insulin-treated T2D; leaves open prospective validation before clinical adoption.
Observational (n=154)
Is the insulin tolerance test (ITT) a valid method for evaluating insulin sensitivity in patients with type 2 diabetes receiving insulin therapy?
p-value: p=<0.001
The insulin tolerance test is a valid method for evaluating insulin sensitivity in patients with type 2 diabetes even after insulin therapy.
Okita et al. (2013) conducted an observational in Type 2 diabetes (n=154). Insulin tolerance test (ITT) vs. Euglycemic clamp test was evaluated on Correlation between plasma glucose disappearance rate (KITT) and average glucose infusion rate (M-value) during standard clamp-IR test (p=<0.001). The plasma glucose disappearance rate derived from an insulin tolerance test closely correlated with the euglycemic clamp test M-value (P<0.001) in patients with type 2 diabetes.
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