Key result
CYP4V2 rs13146272 A allele is linked to ~17% higher VTE risk vs. the C allele.
Why the study?
The relationship between venous thromboembolism and the CYP4V2 polymorphism rs13146272 remains unclear due to small sample sizes and variance in genetic analysis models.
Is the CYP4V2 polymorphism rs13146272 associated with an increased risk of venous thromboembolism?
Meta-Analysis (n=15,383)
Is the CYP4V2 polymorphism rs13146272 associated with an increased risk of venous thromboembolism?
Odds Ratio: 1.17 (95% CI 1.11–1.22)
p-value: p=4.3e-10
The CYP4V2 polymorphism rs13146272 A allele is significantly associated with an increased risk of venous thromboembolism in a pooled meta-analysis, though this risk varies by ethnicity.
Authors
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No VTE association in Chinese cohort; leaves open ancestry-specific effects of rs13146272.
Yue et al. (2018) conducted a meta-analysis in Venous thromboembolism (n=15,383). CYP4V2 polymorphism rs13146272 (A allele) vs. C allele was evaluated on Risk of venous thromboembolism (additive model) (OR 1.17, 95% CI 1.11-1.22, p=4.3e-10). The CYP4V2 polymorphism rs13146272 A allele significantly increased the risk of venous thromboembolism compared to the C allele under an additive model (OR 1.17).
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