Key result
Flumazenil reversal of midazolam sedation did not result in resedation preventing discharge within 2 hours, provided patients responded to verbal command post-sedation.
Why the study?
Does flumazenil cause resedation compared to placebo in healthy patients sedated with midazolam for minor oral surgery?
RCT (n=30)
Double-blind
Cross-over
Does flumazenil cause resedation compared to placebo in healthy patients sedated with midazolam for minor oral surgery?
Flumazenil effectively reverses midazolam sedation without causing clinically significant resedation within two hours in patients undergoing minor oral surgery.
Flumazenil reversal permits safe earlier discharge after midazolam sedation; confirms absence of clinically relevant resedation in this RCT.
In order to find out whether resedation occurred following antagonism with flumazenil of sedation for minor oral surgery, in a double-blind randomised cross-over study thirty healthy Hong Kong Chinese patients undergoing bilateral third molar surgery at two visits were sedated with midazolam. Following surgery they received either flumazenil or placebo at one visit and the alternative at the other visit. Recovery was monitored by observation and objective tests. Following recovery they were monitored for resedation for a total period of two hours from the injection of the reversal agent. Resedation, sufficient to prevent a patient from being discharged to be accompanied home with an escort, did not occur provided the patient responded to verbal command following sedation.
No takes yet. Share an insight, caveat, or question.
Rodrigo et al. (1992) conducted an RCT in Conscious sedation for minor oral surgery (n=30). Flumazenil vs. Placebo was evaluated on Resedation sufficient to prevent discharge. Flumazenil reversal of midazolam sedation did not result in resedation preventing discharge within 2 hours, provided patients responded to verbal command post-sedation.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: