Key result
Flumazenil reversed midazolam-induced psychomotor impairments but not its amnesic effects, without causing resedation for up to 6 hours postoperatively.
Why the study?
Does flumazenil reverse the psychomotor and amnesic effects of midazolam in patients undergoing day-care urological surgery?
Does flumazenil reverse the psychomotor and amnesic effects of midazolam in patients undergoing day-care urological surgery?
Flumazenil effectively reverses midazolam-induced psychomotor impairment but does not affect amnesia, without causing resedation up to 6 hours postoperatively.
May hasten psychomotor recovery after midazolam without resedation; hypothesis-generating for persistent amnesia in day-case settings.
Forty-four patients given midazolam prior to day-care urological surgery had the benzodiazepine antagonist, flumazenil, or placebo administered postoperatively. Flumazenil reversed the psychomotor impairments induced by midazolam but not its amnesic effects. There was no evidence of resedation for up to 6 h following the use of flumazenil.
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Birch et al. (1990) studied this question. Flumazenil reversed midazolam-induced psychomotor impairments but not its amnesic effects, without causing resedation for up to 6 hours postoperatively.
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