Key result
Higher plasma total oxidative status linked to ~4% increased postoperative AF risk after CABG.
Why the study?
The role of oxidative stress related to ischemia-reperfusion damage in the pathogenesis of atrial fibrillation after coronary artery bypass graft surgery was unclear.
Does oxidative stress related to ischemia-reperfusion damage predict the development of postoperative atrial fibrillation in patients undergoing elective on-pump CABG?
Population
118 patients undergoing elective isolated on-pump CABG surgery
Comparison
Patients who developed postoperative atrial fibrillation vs patients who remained in sinus rhythm
Design
Prospective single-center observational study
Follow-up
Postoperative hospital stay
Authors
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TOS may aid POAF risk stratification after CABG; hypothesis-generating for antioxidant interventions in prospective trials.
Observational (n=118)
No
Does oxidative stress related to ischemia-reperfusion damage predict the development of postoperative atrial fibrillation in patients undergoing elective on-pump CABG?
Odds Ratio: 1.04 (95% CI 1.02–1.05)
p-value: p=0.040
Increased plasma total oxidative status during aortic cross-clamping is an independent predictor of postoperative atrial fibrillation following on-pump CABG surgery.
Veysel Oktay (2014) conducted an observational in Postoperative atrial fibrillation (POAF) (n=118). Plasma total oxidative status (TOS) level was evaluated on Postoperative atrial fibrillation (POAF) (OR 1.040, 95% CI 1.020-1.050, p=0.040). Higher plasma total oxidative status (TOS) levels independently predicted the development of postoperative atrial fibrillation after CABG surgery (OR 1.040; 95% CI 1.020-1.050; p=0.040).
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