Pain Relieving Properties of Ginger (Z. officinale) and Echinacea (E. angustifolia) Extracts Supplementation among Female Patients with Osteoarthritis. A Randomized Study

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Advances in Medical, Dental and Health Sciences,2020,3,3,45-48.DOI:10.5530/amdhs.2020.3.11Published:October 2020Type:Research ArticleAuthors:Louay Labban, Maysoun Kudsi, Zeina Malek, and Nasser Thallaj Author(s) affiliations:Louay Labban1,*, Maysoun Kudsi2,4, Zeina Malek3, Nasser Thallaj4 1Faculty of Pharmacy, Al Jazeera Private University, Damascus, SYRIA. 2Faculty of Medicine, Damascus University, Damascus, SYRIA. 3Faculty of Pharmacy, Syrian Private University, Damascus, SYRIA. 4Faculty of Pharmacy, Al Rasheed Private University, SYRIA.Abstract:Objectives: To evaluate the efficacy and safety of the Echinacea and ginger species extracts supplementation among patients with knee osteoarthritis (OA). Methods: Three hundred female patients with knee OA participated in this randomized study. They had OA of the knee and moderate-to-severe pain and they were divided into two groups. Study group (n=150) and control group (n=150). The study which lasted for 6-week. The study group received Ginger and Echinacea extract supplementations twice daily, with/ without acetaminophen. The study examined the reduction in "knee pain on standing for the study group (Ginger and Echinacea group)" defined by a reduction in pain of > or = 15 mm on a visual analog scale. The study measured other biological values such as BP, ESR, Creatinine and liver enzymes. Results: The supplementation of ginger and Echinacea extracts resulted in improvements in many values. Systolic blood pressure dropped from 120.5 ± 10.4 to 119.7 ± 8.9 mmHg, pain intensity VAS decreased from 6.9 ± 2.1 to 6.6 ± 1.5, ESR17.3 ± 11.9 and 21.0 ± 9.8mm/h, creatinine 0.87 ± 0.19mg/dl and 0.85 ± 0.16 mg/ dl and liver enzymes 21.6 ± 8.5 IU/L and 20.9 ± 4.5 IU/L for ALT and 20.9 ± 4.5 IU/L and 20.3 ± 7.4 IU/L for AST. Conclusion: The use of ginger extract in knee osteoarthritis patients had a moderately statistically significant effect on reducing pain with safe profile and mild GI adverse events. Keywords:Echinacea, Ginger, Knee OA, Osteoarthritis, tumor necrosis factor (TNF)-α, visual analogue scale (VAS)View:PDF (513.2 KB)