Key result
Ets-1 expression was significantly higher at invasive sites compared with intraepithelial spread sites (P<0.0001) and at deep margin areas compared with center areas (P<0.05).
Why the study?
Does Ets-1 expression correlate with tumor progression and invasion depth in patients with squamous cell carcinoma of the esophagus?
Population
90 patients with squamous cell carcinoma of the esophagus
Design
Cross-sectional
Authors
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Ets-1 may mark invasive potential in esophageal SCC; leaves open its value as progression biomarker pending prospective validation.
Observational (n=90)
Does Ets-1 expression correlate with tumor progression and invasion depth in patients with squamous cell carcinoma of the esophagus?
p-value: p=<0.0001
Ets-1 expression is significantly higher at invasive sites and deep margins, suggesting it plays an important role in penetrating tumor progression in esophageal squamous cell carcinoma.
Saeki et al. (2000) conducted an observational in Squamous cell carcinoma of the esophagus (n=90). Ets-1 expression vs. Intraepithelial spread sites and center areas was evaluated on Ets-1 positive ratio (p=<0.0001). Ets-1 expression was significantly higher at invasive sites compared with intraepithelial spread sites (P<0.0001) and at deep margin areas compared with center areas (P<0.05).