Key result
Normal pregnancy was associated with significantly increased mean serum ischemia-modified albumin levels compared with non-pregnant healthy women.
Why the study?
Are serum ischemia-modified albumin (IMA) levels increased in normal pregnancies compared to non-pregnant healthy women?
Case-Control (n=117)
Are serum ischemia-modified albumin (IMA) levels increased in normal pregnancies compared to non-pregnant healthy women?
Serum ischemia-modified albumin (IMA), a clinical marker of myocardial ischemia, is physiologically elevated during normal pregnancy, which must be accounted for to avoid false-positive interpretations in pregnant patients.
Elevated IMA in normal pregnancy warrants interpretive caution; leaves open need for pregnancy-specific reference ranges.
The aim of this prospective case-control study was to determine the change in serum maternal ischemia-modified albumin (IMA) during normal pregnancies. A total of 117 pregnant (first trimester (n=24), second trimester (n=34), and third trimester (n=35)) and non-pregnant healthy women (n=23) were included. Maternal serum IMA, Malondialdehyde (MDA), and albumin levels were measured. Compared with non-pregnant women, the cross-sectional mean IMA levels in pregnant women were significantly increased, while the mean serum MDA and albumin levels were significantly decreased throughout pregnancy. Furthermore, a significant negative correlation between serum IMA and albumin levels (r=-0.354, p<0.001) was found, and there was a weak positive correlation between serum albumin and MDA levels (r=0.334, p<0.001). Serum IMA, which has recently been developed as a clinical marker of ongoing myocardial ischemia, appears to be elevated in normal pregnancy. This may be due to the physiologic oxidative stress state of pregnancy.
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Güven et al. (2009) conducted a case-control in Normal pregnancy (n=117). Pregnancy vs. Non-pregnant healthy women was evaluated on Serum maternal ischemia-modified albumin (IMA) levels. Normal pregnancy was associated with significantly increased mean serum ischemia-modified albumin levels compared with non-pregnant healthy women.
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