Key result
An 8-week weight loss regime reduced CRP in overweight women without PCOS (-1.2 mg/L, P=0.025) but not in those with PCOS (P=0.016 for interaction).
Why the study?
Does an 8-week weight loss regime reduce CRP levels differently in overweight women with versus without PCOS?
Population
32 overweight women, comprising 15 with polycystic ovary syndrome and 17 BMI-matched women without PCOS.
Comparison
8-week weight loss regime. vs Women without PCOS undergoing the same 8-week…
Design
Cohort
Follow-up
8 weeks
Authors
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Short-term weight loss may not lower CRP in overweight women with PCOS; leaves open whether greater loss or PCOS-specific approaches are needed.
Cohort (n=32)
Does an 8-week weight loss regime reduce CRP levels differently in overweight women with versus without PCOS?
p-value: p=0.016
A 4-5% weight loss improves metabolic profiles in overweight women but is insufficient to lower CRP in women with PCOS, suggesting they may require greater weight loss for equivalent cardiovascular benefit.
Moran et al. (2007) conducted a cohort in Polycystic Ovary Syndrome (PCOS) and Overweight (n=32). 8-week weight loss regime vs. non-PCOS women was evaluated on Change in C-reactive protein (CRP) (p=0.016). An 8-week weight loss regime reduced CRP in overweight women without PCOS (-1.2 mg/L, P=0.025) but not in those with PCOS (P=0.016 for interaction).
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