Key result
Genetic ablation of caveolin-1 in murine cerebral artery smooth muscle cells resulted in an approximately twofold higher frequency of Ca2+ sparks and transient K(Ca) currents compared to control cells.
Population
Murine cerebral artery smooth muscle cells
Comparison
Genetic ablation of caveolin-1 (cav-1(-/-)) vs Control (cav-1(+/+)) cells
Design
Preclinical
Authors
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Caveolin-1 regulates cerebral artery Ca2+ sparks in mice; extends mechanistic insight but leaves open human cerebrovascular relevance.
Caveolin-1 is required for physiological Ca(2+) spark and transient K(Ca) current regulation in cerebral artery smooth muscle cells.
Cheng et al. (2006) studied this question. Genetic ablation of caveolin-1 (cav-1(-/-)) vs. Control (cav-1(+/+)) cells was evaluated on Ca(2+) spark and transient K(Ca) current frequency. Genetic ablation of caveolin-1 in murine cerebral artery smooth muscle cells resulted in an approximately twofold higher frequency of Ca2+ sparks and transient K(Ca) currents compared to control cells.
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